Beilstein J. Org. Chem.2013,9, 1837–1842, doi:10.3762/bjoc.9.214
Skrollan Stockinger Oliver Trapp Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany 10.3762/bjoc.9.214 Abstract A new approach for the investigation of a higher-order reaction by on-columnreactiongaschromatography is
; cycloaddition; Diels–Alder reaction; flow chemistry; gas chromatography; on-columnreactiongaschromatography; Introduction
The combination of synthesis and analysis in a single experiment offers many advantages. Time-consuming steps, i.e. work-up and separation of the reaction products, can be minimized, and
, which is discussed in the present contribution.
Here, we use a focusing technique to concentrate and stop separating several substances in a single column section to study higher-order reactions and to increase the conversion in on-columnreactiongaschromatography (ocRGC). The major challenge in
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Graphical Abstract
Figure 1:
Overview of some capabilities of an immobilized or in an inert stationary phase dissolved catalyst....